JXL069 Solution 0.5mg/mL 30mL

Yes. Every product and batch gets tested by a third-party US-based laboratory for molecular structure and purity and concentration to ensure it meets our standards. See the “Lab Reports” tab for the third-party lab results.

Short answer: PP405 is a name that appears in the UK5099 based MPC inhibitor literature. The material we supply is JXL069 at 99%+ purity. Some researchers have speculated that JXL069 and PP405 are the same chemical, but we list and describe this product only as JXL069 and do not state that it is PP405 unless future structural data clearly shows a one to one match.

Why some researchers link JXL069 and PP405

• Series origin: JXL069 belongs to the UK5099 based mitochondrial pyruvate carrier (MPC) inhibitor series.
• Design features: in that series, follow up candidates were built by moving to a nitrogen containing fused ring scaffold and introducing a benzyl group with 3,5 bis trifluoromethyl substitution. JXL069 combines exactly this fused ring pattern with a 3,5 bis trifluoromethyl benzyl group on the ring nitrogen.
• MPC activity: JXL069 shows an MPC IC50 of 43nM in the same assay lineage, indicating substantially higher inhibitory activity than the original UK5099 scaffold.
• Position in the series: in the available data JXL069 is described as one of the stronger performing MPC inhibitor candidates within that chemical series, so it is a natural focus when PP405 is discussed in that context.

Why we do not label it as PP405

• The exact structure associated with the PP405 name in the original program has not been fully disclosed.
• Without that structural information, stating that JXL069 is PP405 would go beyond the available data, so we keep the formal name as JXL069 and present the series background and activity profile for researchers to evaluate.

In summary, we supply JXL069 as a 99%+ purity MPC inhibitor solution at 0.5mg/mL and describe its origin and properties within the UK5099 series. PP405 is treated as a literature and search term in this context, not as the product name, unless future structural data confirms a one to one match.

JXL069 is dissolved in a customized solvent mixture based on dimethyl isosorbide DMI, propylene glycol and ethanol.

The exact composition and mixing procedure are proprietary at this point. Because JXL069 is challenging to dissolve in more conventional vehicles, this solvent mixture was developed specifically to obtain a clear, stable 0.5mg/mL solution that meets our internal QC criteria for homogeneity and stability.